Angler Imputation™
High-Resolution Immunogenomics From Microarray Data
Angler Imputation converts standard microarray data into high accuracy, 3-field HLA typing across 45 immune genes.
Performance Where Standard Methods Fall Short
Whether you're currently using PCR-based detection methods, serology, or other imputation tools, Angler delivers the resolution and scale your research demands: clinical-grade accuracy, 45-gene coverage across MHC in a single test, and reliable performance across diverse populations.
>95% Accuracy for 3-Field HLA Typing
Achieve clinical-grade precision & resolution across all major class I and class II HLA genes
45 Genes in One Analysis
Go beyond classical HLA and resolve non-classical loci such as MICA/MICB, TAP genes, and more
Built for Global Diversity
2-4x better performance in non-European populations compared to existing imputation tools
Simple Workflow, Superior Results
Move from partial gene coverage and low-resolution typing to comprehensive 45-gene analysis at 3-field resolution. Generate data on any compatible array, upload to our secure platform, and receive complete results in minutes.
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Run samples on any microarray platform
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Infinium Arrays: GSA, GCRA, GDA
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Axiom Arrays: PMDA, BloodGenomiX
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Your custom array
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Transfer and analyze data on Benthic Platform
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Secure data transfer
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Simple web interface
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Analysis of thousands of samples in just a few minutes
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Get accurate results for complex regions
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Filter and sort data for export in CSV format
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Download a PDF of HLA typing with known drug associations & allele frequency
Built on Superior Reference Architecture That Connects the Dots
Our graph-based reference doesn't just catalog variants – it connects them. Built from thousands of diverse, phased haplotypes, this interconnected architecture reveals the complete picture in complex regions like HLA, delivering >95% accuracy at 3-field resolution.
Supporting Critical Research Applications
From transplantation matching to autoimmune disease studies, Angler provides the high-resolution immune gene data researchers need. For labs using PCR-based detection methods or serology, this means accessing 45 genes in one test instead of running multiple assays. For those with microarrays, it means extracting NGS-quality data from existing infrastructure.
Transplantation Research
High-resolution HLA matching for HSCT and solid organ studies
Immuno-Oncology
Characterize patient immune profile and immunotherapy response markers
Autoimmune Disease
Study HLA associations in T1D, MS, RA, lupus, and neurodegeneration
Population Genomics
Add high-resolution immune profiling to biobank-scale studies
Pharmacogenomics
Profile polymorphic drug response genes alongside HLA
Angler Frequently Asked Questions
Let’s Resolve Your Most Complex Genomic Regions
Get in touch to try our platform on your own microarray or NGS data.